E-ISSN 2636-834X
 

Original Research 


Orbitofrontal Cortex and Thalamus Volumes in Patients with Delusional Disorder

Osman Mermi, Denizhan Keles, Mehmet Caglar Kilic, Sema Baykara, Sevda Korkmaz, Murad Atmaca.

Abstract
Objective: We aimed to examine whether clinical similarity might also reflect to neuroanatomical regions of the brain, orbitofrontal cortex (OFC) and thalamus which seem to be important in the neuroanatomy of OCD and hypochondriasis.
Methods: Volumes of OFC and thalamus were measured in eighteen patients and the same number of healthy control subjects. Manual tracing method was used when measured.
Results: The mean left and right sides of volumes of the OFC were statistically significantly smaller than those of healthy control subjects whereas both sides of thalamus volumes were statistically significantly larger than those of healthy ones. When an ANCOVA, with the covariates of age, gender, and total brain volumes as covariates, was performed, we seen that statistical significance showing that the OFC volumes were reduced in patients with delusional disorder compared to those of healthy control subjects and that thalamus volumes were greater in the patient group than those of healthy comparisons were maintained
Conclusion: In conclusion, we found that patients with the delusional disorder had statistically significantly smaller volumes of the OFC and greater thalamus volumes compared to those of healthy control ones on both sides. As hypothesized by us, the clinical similarity was also reflected in neuroanatomical regions of the brain, OFC and thalamus which seem to be important in the neuroanatomy of OCD and hypochondriasis. However, our results require replication.

Key words: OFC, Delusional Disorder, Thalamus, Volumes


 
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How to Cite this Article
Pubmed Style

Mermi O, Keles D, Kilic MC, Baykara S, Korkmaz S, Atmaca M. Orbitofrontal Cortex and Thalamus Volumes in Patients with Delusional Disorder. PBS. 2021; 11(1): 72-79. doi:10.5455/PBS.20210313022736


Web Style

Mermi O, Keles D, Kilic MC, Baykara S, Korkmaz S, Atmaca M. Orbitofrontal Cortex and Thalamus Volumes in Patients with Delusional Disorder. http://www.pbsciences.org/?mno=302645377 [Access: July 26, 2021]. doi:10.5455/PBS.20210313022736


AMA (American Medical Association) Style

Mermi O, Keles D, Kilic MC, Baykara S, Korkmaz S, Atmaca M. Orbitofrontal Cortex and Thalamus Volumes in Patients with Delusional Disorder. PBS. 2021; 11(1): 72-79. doi:10.5455/PBS.20210313022736



Vancouver/ICMJE Style

Mermi O, Keles D, Kilic MC, Baykara S, Korkmaz S, Atmaca M. Orbitofrontal Cortex and Thalamus Volumes in Patients with Delusional Disorder. PBS. (2021), [cited July 26, 2021]; 11(1): 72-79. doi:10.5455/PBS.20210313022736



Harvard Style

Mermi, O., Keles, . D., Kilic, . M. C., Baykara, . S., Korkmaz, . S. & Atmaca, . M. (2021) Orbitofrontal Cortex and Thalamus Volumes in Patients with Delusional Disorder. PBS, 11 (1), 72-79. doi:10.5455/PBS.20210313022736



Turabian Style

Mermi, Osman, Denizhan Keles, Mehmet Caglar Kilic, Sema Baykara, Sevda Korkmaz, and Murad Atmaca. 2021. Orbitofrontal Cortex and Thalamus Volumes in Patients with Delusional Disorder. Psychiatry and Behavioral Sciences, 11 (1), 72-79. doi:10.5455/PBS.20210313022736



Chicago Style

Mermi, Osman, Denizhan Keles, Mehmet Caglar Kilic, Sema Baykara, Sevda Korkmaz, and Murad Atmaca. "Orbitofrontal Cortex and Thalamus Volumes in Patients with Delusional Disorder." Psychiatry and Behavioral Sciences 11 (2021), 72-79. doi:10.5455/PBS.20210313022736



MLA (The Modern Language Association) Style

Mermi, Osman, Denizhan Keles, Mehmet Caglar Kilic, Sema Baykara, Sevda Korkmaz, and Murad Atmaca. "Orbitofrontal Cortex and Thalamus Volumes in Patients with Delusional Disorder." Psychiatry and Behavioral Sciences 11.1 (2021), 72-79. Print. doi:10.5455/PBS.20210313022736



APA (American Psychological Association) Style

Mermi, O., Keles, . D., Kilic, . M. C., Baykara, . S., Korkmaz, . S. & Atmaca, . M. (2021) Orbitofrontal Cortex and Thalamus Volumes in Patients with Delusional Disorder. Psychiatry and Behavioral Sciences, 11 (1), 72-79. doi:10.5455/PBS.20210313022736