E-ISSN 2636-834X
 

Original Research 


A Cross-sectional, Comparative Study of Oxidative Metabolism and Oxidative DNA Damage in Adult Attention Deficit and Hyperactivity Disorder

Ihsan Aksoy, Volkan Gucyetmez, Osman Hasan Tahsin Kilic, Ahmet Unal, Abdurrahman Altindag.

Abstract
Objective: Oxidative metabolism abnormalities are gaining attention as an important factor for psychiatric disorders including attention deficit and hyperactivity disorder (ADHD). Only a handful of studies have investigated the possible relation between adult ADHD and oxidative stress. However, we found no research about oxidative DNA damage among adult ADHD patients.
Methods: The study comprised of 43 A-ADHD patients and 30 healthy controls. Serum total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) and 8-hydroxy-2′- deoxyguanosine (8-OHdG) levels were measured and compared in cross-sectional design.
Results: No difference was observed in terms of oxidative stress and oxidative DNA damage across groups. Patients with comorbid psychiatric diagnosis had significantly increased TOS and OSI levels when compared with patients who had no comorbidity.
Conclusion: According to our results, oxidative balance among adult ADHD patients were not impaired. This result is discordant with the majority of the findings of the studies performed in children and adolescents and animals. Oxidative stress may not have a specific role in the ethiopathogenesis of ADHD in adults.

Key words: Adult ADHD, oxidative balance, 8-hydroxy-2′- deoxyguanosine


 
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How to Cite this Article
Pubmed Style

Aksoy I, Gucyetmez V, Kilic OHT, Unal A, Altindag A. A Cross-sectional, Comparative Study of Oxidative Metabolism and Oxidative DNA Damage in Adult Attention Deficit and Hyperactivity Disorder. PBS. 2020; 10(2): 80-85. doi:10.5455/PBS.20190626065655


Web Style

Aksoy I, Gucyetmez V, Kilic OHT, Unal A, Altindag A. A Cross-sectional, Comparative Study of Oxidative Metabolism and Oxidative DNA Damage in Adult Attention Deficit and Hyperactivity Disorder. http://www.pbsciences.org/?mno=54160 [Access: September 29, 2021]. doi:10.5455/PBS.20190626065655


AMA (American Medical Association) Style

Aksoy I, Gucyetmez V, Kilic OHT, Unal A, Altindag A. A Cross-sectional, Comparative Study of Oxidative Metabolism and Oxidative DNA Damage in Adult Attention Deficit and Hyperactivity Disorder. PBS. 2020; 10(2): 80-85. doi:10.5455/PBS.20190626065655



Vancouver/ICMJE Style

Aksoy I, Gucyetmez V, Kilic OHT, Unal A, Altindag A. A Cross-sectional, Comparative Study of Oxidative Metabolism and Oxidative DNA Damage in Adult Attention Deficit and Hyperactivity Disorder. PBS. (2020), [cited September 29, 2021]; 10(2): 80-85. doi:10.5455/PBS.20190626065655



Harvard Style

Aksoy, I., Gucyetmez, . V., Kilic, . O. H. T., Unal, . A. & Altindag, . A. (2020) A Cross-sectional, Comparative Study of Oxidative Metabolism and Oxidative DNA Damage in Adult Attention Deficit and Hyperactivity Disorder. PBS, 10 (2), 80-85. doi:10.5455/PBS.20190626065655



Turabian Style

Aksoy, Ihsan, Volkan Gucyetmez, Osman Hasan Tahsin Kilic, Ahmet Unal, and Abdurrahman Altindag. 2020. A Cross-sectional, Comparative Study of Oxidative Metabolism and Oxidative DNA Damage in Adult Attention Deficit and Hyperactivity Disorder. Psychiatry and Behavioral Sciences, 10 (2), 80-85. doi:10.5455/PBS.20190626065655



Chicago Style

Aksoy, Ihsan, Volkan Gucyetmez, Osman Hasan Tahsin Kilic, Ahmet Unal, and Abdurrahman Altindag. "A Cross-sectional, Comparative Study of Oxidative Metabolism and Oxidative DNA Damage in Adult Attention Deficit and Hyperactivity Disorder." Psychiatry and Behavioral Sciences 10 (2020), 80-85. doi:10.5455/PBS.20190626065655



MLA (The Modern Language Association) Style

Aksoy, Ihsan, Volkan Gucyetmez, Osman Hasan Tahsin Kilic, Ahmet Unal, and Abdurrahman Altindag. "A Cross-sectional, Comparative Study of Oxidative Metabolism and Oxidative DNA Damage in Adult Attention Deficit and Hyperactivity Disorder." Psychiatry and Behavioral Sciences 10.2 (2020), 80-85. Print. doi:10.5455/PBS.20190626065655



APA (American Psychological Association) Style

Aksoy, I., Gucyetmez, . V., Kilic, . O. H. T., Unal, . A. & Altindag, . A. (2020) A Cross-sectional, Comparative Study of Oxidative Metabolism and Oxidative DNA Damage in Adult Attention Deficit and Hyperactivity Disorder. Psychiatry and Behavioral Sciences, 10 (2), 80-85. doi:10.5455/PBS.20190626065655