E-ISSN 2636-834X
 

Original Research 


Elevated Monocyte Levels Maybe a Common Peripheral Inflammatory Marker in Specific Learning Disorders and Attention Deficit/Hyperactivity Disorder

Cigdem Yektas, Ali Evren Tufan, Onder Kilicaslan, Merve Yazici, Sumeyra Elif Kaplan Karakaya, Enes Sarigedik.

Abstract
Aim: the primary aim of this study was to determine whether the neutrophil / lymphocyte ratio, mean platelet volume, monocyte/ lymphocyte ratio and distribution width of red blood cells are different in children with specific learning disorders compared to healthy controls. The second aim of the study is to investigate the relationships of those inflammatory markers with SLDs clinical severity.
Methods: A total of 100 drug-naive participants, aged 7-12 years, who were newly diagnosed as having specific learning disorders according to the DSM-5 criteria were compared with a healthy control group of 75 age, sex matched children. the neutrophil / lymphocyte ratio, mean platelet volume, monocyte/ lymphocyte ratio and distribution width of red blood cells were measured according to the complete blood count.
Results: specific learning disorders significantly affected monocyte levels and tended to affect monocyte/ lymphocyte ratio and neutrophil levels while attention deficit hyperactivity disorder diagnosis significantly affected monocyte levels and mean platelet volume and also tended to affect distribution width of red blood cells. Specific learning disorders symptom severity did not correlate significantly with peripheral inflammatory markers.
Conclusions: This study is the first to investigate the effect of peripheral inflammatory markers in a large specific learning disorders sample by controlling attention deficit hyperactivity disorder comorbidity. The findings demonstrated that the monocyte levels are higher in both specific learning disorders and attention deficit hyperactivity disorder groups suggesting that elevated monocyte levels may be a common marker in the inflammatory pathophysiology.

Key words: Key words: mean platelet volume, monocyte, monocyte/lymphocyte ratio, platelet/lymphocyte ratio, specific learning disorders


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Cigdem Yektas
Articles by Ali Evren Tufan
Articles by Onder Kilicaslan
Articles by Merve Yazici
Articles by Sumeyra Elif Kaplan Karakaya
Articles by Enes Sarigedik
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Yektas C, Tufan AE, Kilicaslan O, Yazici M, Karakaya SEK, Sarigedik E. Elevated Monocyte Levels Maybe a Common Peripheral Inflammatory Marker in Specific Learning Disorders and Attention Deficit/Hyperactivity Disorder. PBS. 2022; 12(3): 125-133. doi:10.5455/PBS.20210518080022


Web Style

Yektas C, Tufan AE, Kilicaslan O, Yazici M, Karakaya SEK, Sarigedik E. Elevated Monocyte Levels Maybe a Common Peripheral Inflammatory Marker in Specific Learning Disorders and Attention Deficit/Hyperactivity Disorder. https://www.pbsciences.org/?mno=82237 [Access: October 02, 2022]. doi:10.5455/PBS.20210518080022


AMA (American Medical Association) Style

Yektas C, Tufan AE, Kilicaslan O, Yazici M, Karakaya SEK, Sarigedik E. Elevated Monocyte Levels Maybe a Common Peripheral Inflammatory Marker in Specific Learning Disorders and Attention Deficit/Hyperactivity Disorder. PBS. 2022; 12(3): 125-133. doi:10.5455/PBS.20210518080022



Vancouver/ICMJE Style

Yektas C, Tufan AE, Kilicaslan O, Yazici M, Karakaya SEK, Sarigedik E. Elevated Monocyte Levels Maybe a Common Peripheral Inflammatory Marker in Specific Learning Disorders and Attention Deficit/Hyperactivity Disorder. PBS. (2022), [cited October 02, 2022]; 12(3): 125-133. doi:10.5455/PBS.20210518080022



Harvard Style

Yektas, C., Tufan, . A. E., Kilicaslan, . O., Yazici, . M., Karakaya, . S. E. K. & Sarigedik, . E. (2022) Elevated Monocyte Levels Maybe a Common Peripheral Inflammatory Marker in Specific Learning Disorders and Attention Deficit/Hyperactivity Disorder. PBS, 12 (3), 125-133. doi:10.5455/PBS.20210518080022



Turabian Style

Yektas, Cigdem, Ali Evren Tufan, Onder Kilicaslan, Merve Yazici, Sumeyra Elif Kaplan Karakaya, and Enes Sarigedik. 2022. Elevated Monocyte Levels Maybe a Common Peripheral Inflammatory Marker in Specific Learning Disorders and Attention Deficit/Hyperactivity Disorder. Psychiatry and Behavioral Sciences, 12 (3), 125-133. doi:10.5455/PBS.20210518080022



Chicago Style

Yektas, Cigdem, Ali Evren Tufan, Onder Kilicaslan, Merve Yazici, Sumeyra Elif Kaplan Karakaya, and Enes Sarigedik. "Elevated Monocyte Levels Maybe a Common Peripheral Inflammatory Marker in Specific Learning Disorders and Attention Deficit/Hyperactivity Disorder." Psychiatry and Behavioral Sciences 12 (2022), 125-133. doi:10.5455/PBS.20210518080022



MLA (The Modern Language Association) Style

Yektas, Cigdem, Ali Evren Tufan, Onder Kilicaslan, Merve Yazici, Sumeyra Elif Kaplan Karakaya, and Enes Sarigedik. "Elevated Monocyte Levels Maybe a Common Peripheral Inflammatory Marker in Specific Learning Disorders and Attention Deficit/Hyperactivity Disorder." Psychiatry and Behavioral Sciences 12.3 (2022), 125-133. Print. doi:10.5455/PBS.20210518080022



APA (American Psychological Association) Style

Yektas, C., Tufan, . A. E., Kilicaslan, . O., Yazici, . M., Karakaya, . S. E. K. & Sarigedik, . E. (2022) Elevated Monocyte Levels Maybe a Common Peripheral Inflammatory Marker in Specific Learning Disorders and Attention Deficit/Hyperactivity Disorder. Psychiatry and Behavioral Sciences, 12 (3), 125-133. doi:10.5455/PBS.20210518080022