Article Type: Original Articles
Patients with First Episode Psychosis and Chronic Schizophrenia may not Differ in Mean Platelet Volume Affecting its Value as an Indicator of Cardiovascular Disease
Musa Sahpolat, Mustafa Ari

Objective: The aim of the present study was to examine differences in terms of mean platelet volume (MPV) in patients with first episode psychosis, chronic schizophrenia, and psychiatrically healthy controls and to determine the potential value of MPV for cardiovascular disorders in patients with psychotic disorders.

Methods: A total number of 32 patients with first episode psychosis, 44 patients with chronic schizophrenia, and 43 randomly selected weight- and body mass index-matched psychiatrically healthy controls who presented to the Psychiatry Outpatient Clinic were included. The Positive and Negative Syndrome Scale (PANSS) was administered to the patients group. The body mass index (BMI) was calculated and MPV was measured for each subject.

Results: The mean MPV level was 9.38±1.00 fL in patients with first episode psychosis, 9.60±1.02 fL in patients with chronic schizophrenia, and 9.2±0.94 fL in psychiatrically healthy controls group. MPV levels were not significantly different between the three groups. There were no statistically significant differences between the three groups in terms of platelet count or BMI. There were no statistically significant correlations between the MPV levels and total PANSS scores in the patients groups.

Conclusions: To the best of our knowledge, the present study was the first to evaluate the MPV levels in patients with first episode psychosis. We consider that it is not appropriate for MPV to be used as an indicator for CVDs in patients with psychosis. Better-designed and more advanced studies are necessary to determine the exact function of platelets and the importance of MPV in patients with first episode psychosis and chronic schizophrenia.


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Key words: Chronic schizophrenia, first attack psychosis, mean platelet volume
Psychiatry and Behavioral Sciences 2019;9(4):166-171
Online ISSN: 2636-834X
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