Is there any relationship between sodium and depression?

Osman Özdemir; Yasemin Usul Soyoral; Mesut Işık; Pınar Güzel Özdemir; Ragıp Balahoroglu

doi:10.5455/jmood.20140609102738

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Short Communication
Online Published: 30 Dec 2014

PBS. 2014; 4(4): 163-6

doi: 10.5455/jmood.20140609102738

Is there any relationship between sodium and depression?

Osman Özdemir, Yasemin Usul Soyoral, Mesut Işık, Pınar Güzel Özdemir, Ragıp Balahoroglu.

Abstract
Objective: Some authors have suggested that abnormalities in electrolyte metabolism can cause mood disorders. A few studies have demonstrated relationships between the metabolism of electrolytes and affective symptoms. In this study, we aimed to investigate whether there is any relationship between serum sodium levels and depression.
Methods: The study sample consisted of 42 patients with depressive disorders who were consecutively admitted to the inpatient psychiatric service and 34 healthy control subjects. In the patients group, thirty-five patients (83.3%) had major depression, three (7.1%) had psychotic depression, three (7.1%) had catatonic depression and one (2.3%) had seasonal depression. The serum sodium and serum creatinine levels were measured in a blood sample before eating anything in the morning. Urine sodium, urine creatinine and density of urine were studied in the first morning spot urine sample.
Results: Patients with depression had significantly lower serum sodium than healthy control subjects (p=0.04). No significant differences between the groups in terms of plasma creatinine, urine sodium, urine creatinine and density of urine.
Conclusions: The present study suggest that there might be a relationship between serum sodium levels and depression.

Key words: electrolyte imbalances, affective disorders, sodium, depression

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How to Cite this Article

Pubmed Style

Ozdemir O, Soyoral YU, Işık M, Ozdemir PG, Balahoroglu R. Is there any relationship between sodium and depression?. PBS. 2014; 4(4): 163-6. doi:10.5455/jmood.20140609102738

Web Style

Ozdemir O, Soyoral YU, Işık M, Ozdemir PG, Balahoroglu R. Is there any relationship between sodium and depression?. https://www.pbsciences.org/?mno=153844 [Access: April 05, 2025]. doi:10.5455/jmood.20140609102738

AMA (American Medical Association) Style

Ozdemir O, Soyoral YU, Işık M, Ozdemir PG, Balahoroglu R. Is there any relationship between sodium and depression?. PBS. 2014; 4(4): 163-6. doi:10.5455/jmood.20140609102738

Vancouver/ICMJE Style

Ozdemir O, Soyoral YU, Işık M, Ozdemir PG, Balahoroglu R. Is there any relationship between sodium and depression?. PBS. (2014), [cited April 05, 2025]; 4(4): 163-6. doi:10.5455/jmood.20140609102738

Harvard Style

Ozdemir, O., Soyoral, . Y. U., Işık, . M., Ozdemir, . P. G. & Balahoroglu, . R. (2014) Is there any relationship between sodium and depression?. PBS, 4 (4), 163-6. doi:10.5455/jmood.20140609102738

Turabian Style

Ozdemir, Osman, Yasemin Usul Soyoral, Mesut Işık, Pınar Guzel Ozdemir, and Ragıp Balahoroglu. 2014. Is there any relationship between sodium and depression?. Psychiatry and Behavioral Sciences, 4 (4), 163-6. doi:10.5455/jmood.20140609102738

Chicago Style

Ozdemir, Osman, Yasemin Usul Soyoral, Mesut Işık, Pınar Guzel Ozdemir, and Ragıp Balahoroglu. "Is there any relationship between sodium and depression?." Psychiatry and Behavioral Sciences 4 (2014), 163-6. doi:10.5455/jmood.20140609102738

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Ozdemir, O., Soyoral, . Y. U., Işık, . M., Ozdemir, . P. G. & Balahoroglu, . R. (2014) Is there any relationship between sodium and depression?. Psychiatry and Behavioral Sciences, 4 (4), 163-6. doi:10.5455/jmood.20140609102738

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