E-ISSN 2636-834X
 

Original Research 


Relationship between serum BDNF levels and cognitive functions, cortisol levels in depressive disorder?

Gülfizar Sözeri-Varma, Yaşar Enli, Emel Aydın, Tuğçe Toker-Uğurlu, Hüseyin Alaçam, Nalan Kalkan-Oğuzhanoğlu.

Abstract
Objective: The objective of this study was to examine the relationship between the serum BDNF levels in depressive disorder patients and cognitive functions along with cortisol levels.
Methods: Thirty patients meeting the DSM-IV criteria for major depressive disorder were recruited for this study. Patients had not used psychotropic drugs. The severity of depression was assessed by the Hamilton Rating of Depression Scale (HAM-D17). Serum BDNF levels were determined by using ELISA. Neuropsychological evaluation included Digit Span Test, Stroop Test, Verbal Memory Processing Test and Weschler-Visual Memory.
Results: HAM-D17 scores were 17.09±4.96 in patients. Serum BDNF levels were established to be 1453.42±144.51 pg/mL, and mean serum morning cortisol level was established as 11.54±4.57 µg/dL. No relationship was determined between the HAM-D17 scores and BDNF levels. The serum BDNF levels were not correlated with cortisol levels, and neuropsychological tests scores. Serum cortisol levels and Stroop test time differences were established to be positively correlated (rs=0.396 p=0.017). Serum cortisol levels were not correlated with other neuropsychogical tests.
Conclusion: No relationship was determined between the BDNF levels and attention and memory performances for patients with depression. It was determined that elevated morning baseline cortisol levels affected attention negatively. There was no correlation between serum BDNF levels and morning cortisol levels.

Key words: depression, BDNF (Brain-derived neurotrophic factor), cortisol, attention, verbal memory, visual memory


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Gülfizar Sözeri-Varma
Articles by Yaşar Enli
Articles by Emel Aydın
Articles by Tuğçe Toker-Uğurlu
Articles by Hüseyin Alaçam
Articles by Nalan Kalkan-Oğuzhanoğlu
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Gulfizar Sozeri-Varma, Yaşar Enli, Emel Aydın, Tuğce Toker-Uğurlu, Huseyin Alacam, Nalan Kalkan-Oğuzhanoğlu. Relationship between serum BDNF levels and cognitive functions, cortisol levels in depressive disorder?. PBS. 2012; 2(2): 58-65. doi:10.5455/jmood.20120619051904


Web Style

Gulfizar Sozeri-Varma, Yaşar Enli, Emel Aydın, Tuğce Toker-Uğurlu, Huseyin Alacam, Nalan Kalkan-Oğuzhanoğlu. Relationship between serum BDNF levels and cognitive functions, cortisol levels in depressive disorder?. https://www.pbsciences.org/?mno=17096 [Access: December 15, 2023]. doi:10.5455/jmood.20120619051904


AMA (American Medical Association) Style

Gulfizar Sozeri-Varma, Yaşar Enli, Emel Aydın, Tuğce Toker-Uğurlu, Huseyin Alacam, Nalan Kalkan-Oğuzhanoğlu. Relationship between serum BDNF levels and cognitive functions, cortisol levels in depressive disorder?. PBS. 2012; 2(2): 58-65. doi:10.5455/jmood.20120619051904



Vancouver/ICMJE Style

Gulfizar Sozeri-Varma, Yaşar Enli, Emel Aydın, Tuğce Toker-Uğurlu, Huseyin Alacam, Nalan Kalkan-Oğuzhanoğlu. Relationship between serum BDNF levels and cognitive functions, cortisol levels in depressive disorder?. PBS. (2012), [cited December 15, 2023]; 2(2): 58-65. doi:10.5455/jmood.20120619051904



Harvard Style

Gulfizar Sozeri-Varma, Yaşar Enli, Emel Aydın, Tuğce Toker-Uğurlu, Huseyin Alacam, Nalan Kalkan-Oğuzhanoğlu (2012) Relationship between serum BDNF levels and cognitive functions, cortisol levels in depressive disorder?. PBS, 2 (2), 58-65. doi:10.5455/jmood.20120619051904



Turabian Style

Gulfizar Sozeri-Varma, Yaşar Enli, Emel Aydın, Tuğce Toker-Uğurlu, Huseyin Alacam, Nalan Kalkan-Oğuzhanoğlu. 2012. Relationship between serum BDNF levels and cognitive functions, cortisol levels in depressive disorder?. Psychiatry and Behavioral Sciences, 2 (2), 58-65. doi:10.5455/jmood.20120619051904



Chicago Style

Gulfizar Sozeri-Varma, Yaşar Enli, Emel Aydın, Tuğce Toker-Uğurlu, Huseyin Alacam, Nalan Kalkan-Oğuzhanoğlu. "Relationship between serum BDNF levels and cognitive functions, cortisol levels in depressive disorder?." Psychiatry and Behavioral Sciences 2 (2012), 58-65. doi:10.5455/jmood.20120619051904



MLA (The Modern Language Association) Style

Gulfizar Sozeri-Varma, Yaşar Enli, Emel Aydın, Tuğce Toker-Uğurlu, Huseyin Alacam, Nalan Kalkan-Oğuzhanoğlu. "Relationship between serum BDNF levels and cognitive functions, cortisol levels in depressive disorder?." Psychiatry and Behavioral Sciences 2.2 (2012), 58-65. Print. doi:10.5455/jmood.20120619051904



APA (American Psychological Association) Style

Gulfizar Sozeri-Varma, Yaşar Enli, Emel Aydın, Tuğce Toker-Uğurlu, Huseyin Alacam, Nalan Kalkan-Oğuzhanoğlu (2012) Relationship between serum BDNF levels and cognitive functions, cortisol levels in depressive disorder?. Psychiatry and Behavioral Sciences, 2 (2), 58-65. doi:10.5455/jmood.20120619051904