Peripheral Edema Due to Valproic Acid Use: A Case Report and Review of the Literature

Ömer Naim Sayer; Sefanur Köse; Çiçek Hocaoğlu

doi:10.5455/PBS.20250306085912

Case Report

PBS. 2025; 15(2): 91-98

doi: 10.5455/PBS.20250306085912

Peripheral Edema Due to Valproic Acid Use: A Case Report and Review of the Literature

Ömer Naim Sayer, Sefanur Köse, Çiçek Hocaoğlu.

Abstract
Valproate is used to treat epilepsy, migraine and bipolar disorder. As with many other drugs, case reports indicate that peripheral edema may develop with valproate use, and various mechanisms have been proposed. Herein, we report the development of peripheral edema (bilateral lower extremity, facial and periorbital) in a 36-year-old female patient with bipolar affective disorder 4 days after the initiation of valproate treatment, the edema disappeared in a short time after discontinuation of the drug. We review and discuss 24 cases associated with valproate use previously reported in the literature.

Key words: Edema; Adverse Drug Reaction; Valproate; Sodium Valproate; Valpromide

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How to Cite this Article

Pubmed Style

Sayer ON, Kose S, Hocaoğlu C. Peripheral Edema Due to Valproic Acid Use: A Case Report and Review of the Literature. PBS. 2025; 15(2): 91-98. doi:10.5455/PBS.20250306085912

Web Style

Sayer ON, Kose S, Hocaoğlu C. Peripheral Edema Due to Valproic Acid Use: A Case Report and Review of the Literature. https://www.pbsciences.org/?mno=246054 [Access: November 10, 2025]. doi:10.5455/PBS.20250306085912

AMA (American Medical Association) Style

Sayer ON, Kose S, Hocaoğlu C. Peripheral Edema Due to Valproic Acid Use: A Case Report and Review of the Literature. PBS. 2025; 15(2): 91-98. doi:10.5455/PBS.20250306085912

Vancouver/ICMJE Style

Sayer ON, Kose S, Hocaoğlu C. Peripheral Edema Due to Valproic Acid Use: A Case Report and Review of the Literature. PBS. (2025), [cited November 10, 2025]; 15(2): 91-98. doi:10.5455/PBS.20250306085912

Harvard Style

Sayer, O. N., Kose, . S. & Hocaoğlu, . C. (2025) Peripheral Edema Due to Valproic Acid Use: A Case Report and Review of the Literature. PBS, 15 (2), 91-98. doi:10.5455/PBS.20250306085912

Turabian Style

Sayer, Omer Naim, Sefanur Kose, and Cicek Hocaoğlu. 2025. Peripheral Edema Due to Valproic Acid Use: A Case Report and Review of the Literature. Psychiatry and Behavioral Sciences, 15 (2), 91-98. doi:10.5455/PBS.20250306085912

Chicago Style

Sayer, Omer Naim, Sefanur Kose, and Cicek Hocaoğlu. "Peripheral Edema Due to Valproic Acid Use: A Case Report and Review of the Literature." Psychiatry and Behavioral Sciences 15 (2025), 91-98. doi:10.5455/PBS.20250306085912

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Sayer, O. N., Kose, . S. & Hocaoğlu, . C. (2025) Peripheral Edema Due to Valproic Acid Use: A Case Report and Review of the Literature. Psychiatry and Behavioral Sciences, 15 (2), 91-98. doi:10.5455/PBS.20250306085912

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