E-ISSN 2636-834X
 

Case Report 


Psychotic depression induced by adalimumab in a patient with ankylosing spondylitis: A case report

lale gönenir erbay, fatma kartal sarıoğlu, cengiz darılmaz, şükrü kartalcı.

Abstract
Tumor Necrosis Factor Alpha antagonists, which are used for the treatment of inflammatory diseases, are considered to be associated with psychiatric diseases.Herein we have reported an adult ankylosing spondylitis case with psychotic depression induced by adalimumab therapy and improved after treatment. We aimed both to discuss the relationship between psychiatric disease and inflammatory factor over this case and to make contribution to the literature. A 57-year-old male patient. He had experienced depressive symptoms nearly 5 months ago after 15 days of adalimumab therapy started for ankylosing spondylitis. Meanwhile, the symptoms of the patient, who continued adalimumab therapy once every two weeks, progressed and accompanied by psychotic symptoms such as disorganized speaking and behavior. The patient was admitted to the psychiatry clinic; however, his complaints did not significantly improve with treatment but rapidly regressed after discontinuation of adalimumab therapy. To our knowledge, there is limited data on the mood episodes triggered by adalimumab. In the present case, presence of a connection between symptom onset and the date of starting the medication, as well as rapid symptom regression with discontinuation of the medication, was considered as “potential adverse drug effect” according to the Naranjo Algorithm. This suggests that alteration in proinflammatory processes such as Tumor Necrosis Factor (TNF) might be associated with the onset of mood episodes. Further studies would be important in understanding the role of immune system in the pathophysiology of depression, particularly the sub-types such as psychotic depression.

Key words: Psychotic Depression, Adalimumab, TNF-Alpha Antagonists


 
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How to Cite this Article
Pubmed Style

lale gonenir erbay, fatma kartal sarıoğlu, cengiz darılmaz, şukru kartalcı. Psychotic depression induced by adalimumab in a patient with ankylosing spondylitis: A case report. PBS. 2018; 8(4): -. doi:10.5455/PBS.20180515083252


Web Style

lale gonenir erbay, fatma kartal sarıoğlu, cengiz darılmaz, şukru kartalcı. Psychotic depression induced by adalimumab in a patient with ankylosing spondylitis: A case report. https://www.pbsciences.org/?mno=299209 [Access: December 04, 2023]. doi:10.5455/PBS.20180515083252


AMA (American Medical Association) Style

lale gonenir erbay, fatma kartal sarıoğlu, cengiz darılmaz, şukru kartalcı. Psychotic depression induced by adalimumab in a patient with ankylosing spondylitis: A case report. PBS. 2018; 8(4): -. doi:10.5455/PBS.20180515083252



Vancouver/ICMJE Style

lale gonenir erbay, fatma kartal sarıoğlu, cengiz darılmaz, şukru kartalcı. Psychotic depression induced by adalimumab in a patient with ankylosing spondylitis: A case report. PBS. (2018), [cited December 04, 2023]; 8(4): -. doi:10.5455/PBS.20180515083252



Harvard Style

lale gonenir erbay, fatma kartal sarıoğlu, cengiz darılmaz, şukru kartalcı (2018) Psychotic depression induced by adalimumab in a patient with ankylosing spondylitis: A case report. PBS, 8 (4), -. doi:10.5455/PBS.20180515083252



Turabian Style

lale gonenir erbay, fatma kartal sarıoğlu, cengiz darılmaz, şukru kartalcı. 2018. Psychotic depression induced by adalimumab in a patient with ankylosing spondylitis: A case report. Psychiatry and Behavioral Sciences, 8 (4), -. doi:10.5455/PBS.20180515083252



Chicago Style

lale gonenir erbay, fatma kartal sarıoğlu, cengiz darılmaz, şukru kartalcı. "Psychotic depression induced by adalimumab in a patient with ankylosing spondylitis: A case report." Psychiatry and Behavioral Sciences 8 (2018), -. doi:10.5455/PBS.20180515083252



MLA (The Modern Language Association) Style

lale gonenir erbay, fatma kartal sarıoğlu, cengiz darılmaz, şukru kartalcı. "Psychotic depression induced by adalimumab in a patient with ankylosing spondylitis: A case report." Psychiatry and Behavioral Sciences 8.4 (2018), -. Print. doi:10.5455/PBS.20180515083252



APA (American Psychological Association) Style

lale gonenir erbay, fatma kartal sarıoğlu, cengiz darılmaz, şukru kartalcı (2018) Psychotic depression induced by adalimumab in a patient with ankylosing spondylitis: A case report. Psychiatry and Behavioral Sciences, 8 (4), -. doi:10.5455/PBS.20180515083252