Effects of melatonin and memantine administration on the learning and memory performances of hypoxic juvenile rat pups

Birsen Elibol; Cigdem Sahbaz; Signem Eyuboglu; Burcu Cevreli; Ulkan Kilic; Ertugrul Kilic

doi:10.5455/PBS.20200604064021

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Original Research

PBS. 2020; 10(3): 125-133

doi: 10.5455/PBS.20200604064021

Effects of melatonin and memantine administration on the learning and memory performances of hypoxic juvenile rat pups

Birsen Elibol, Cigdem Sahbaz, Signem Eyuboglu, Burcu Cevreli, Ulkan Kilic, Ertugrul Kilic.

Abstract
Objective: Herein, we aimed to investigate the long-term effects of neonatal hypoxia and the potential protective role of Melatonin (MLT) and Memantine (MEM) on the learning and memory.
Methods: Seven-day-old rat underwent right carotid ligation, followed by hypoxia. Rat received MLT (4 mg/kg), MEM (20 mg/kg), and MLT+MEM combination after hypoxia. We tested these rats for anxiety by elevated O-maze and for spatial learning and memory by Morris water maze (MWM) at postnatal day 45.
Results: Hypoxia increased the level of anxiety compared to the control group (P= 0.05) while treatment of MLT, MEM, and MLT+MEM ameliorated this effect. In addition, hypoxia produced significant decrease in spatial learning of the rats on the fourth day of training (P≤ 0.05) and the percent time spent in the platform quadrant and the entrance frequencies to the platform quadrant compared to the control group (P= 0.049 and P= 0.023). Treatment of MLT, MEM, and MLT+MEM after hypoxia improved the performance of the rats at the third (P= 0.686, P= 0.876, P= 0.977, respectively) and fourth day (P= 0.738, P=0.553, P= 0.789, respectively) of MWM training. The decrease in the percent time spent was ameliorated by the treatment of MLT (P= 0.239), MEM (P= 0.289), and MLT+MEM (P= 0.567) compared to the control group. In addition, MLT treatment significantly increased the entrance frequency to the platform quadrant compared to the hypoxia group (P= 0.020).
Conclusion: Our data suggested that the MLT was more effective in the release of memory deficits from hypoxia-related damage. MLT might have a therapeutic value in improving hypoxic damage in the developing brain.

Key words: Neonatal Hypoxia; Learning; Memory; Melatonin; Memantine; Morris Water Maze

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How to Cite this Article

Pubmed Style

BE, Sahbaz C, SE, Cevreli B, UK, Kilic E. Effects of melatonin and memantine administration on the learning and memory performances of hypoxic juvenile rat pups. PBS. 2020; 10(3): 125-133. doi:10.5455/PBS.20200604064021

Web Style

BE, Sahbaz C, SE, Cevreli B, UK, Kilic E. Effects of melatonin and memantine administration on the learning and memory performances of hypoxic juvenile rat pups. https://www.pbsciences.org/?mno=77050 [Access: April 08, 2024]. doi:10.5455/PBS.20200604064021

AMA (American Medical Association) Style

BE, Sahbaz C, SE, Cevreli B, UK, Kilic E. Effects of melatonin and memantine administration on the learning and memory performances of hypoxic juvenile rat pups. PBS. 2020; 10(3): 125-133. doi:10.5455/PBS.20200604064021

Vancouver/ICMJE Style

BE, Sahbaz C, SE, Cevreli B, UK, Kilic E. Effects of melatonin and memantine administration on the learning and memory performances of hypoxic juvenile rat pups. PBS. (2020), [cited April 08, 2024]; 10(3): 125-133. doi:10.5455/PBS.20200604064021

Harvard Style

, B. E., Sahbaz, . C., , . S. E., Cevreli, . B., , . U. K. & Kilic, . E. (2020) Effects of melatonin and memantine administration on the learning and memory performances of hypoxic juvenile rat pups. PBS, 10 (3), 125-133. doi:10.5455/PBS.20200604064021

Turabian Style

, Birsen Elibol, Cigdem Sahbaz, Signem Eyuboglu, Burcu Cevreli, Ulkan Kilic, and Ertugrul Kilic. 2020. Effects of melatonin and memantine administration on the learning and memory performances of hypoxic juvenile rat pups. Psychiatry and Behavioral Sciences, 10 (3), 125-133. doi:10.5455/PBS.20200604064021

Chicago Style

, Birsen Elibol, Cigdem Sahbaz, Signem Eyuboglu, Burcu Cevreli, Ulkan Kilic, and Ertugrul Kilic. "Effects of melatonin and memantine administration on the learning and memory performances of hypoxic juvenile rat pups." Psychiatry and Behavioral Sciences 10 (2020), 125-133. doi:10.5455/PBS.20200604064021

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

, B. E., Sahbaz, . C., , . S. E., Cevreli, . B., , . U. K. & Kilic, . E. (2020) Effects of melatonin and memantine administration on the learning and memory performances of hypoxic juvenile rat pups. Psychiatry and Behavioral Sciences, 10 (3), 125-133. doi:10.5455/PBS.20200604064021

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