The Effects of Treatment Regimens in Accordance with International Guidelines Among Turkish Patients with Schizophrenia: A Single-Center Naturalistic Observation Study

Serdar Atik; Abdullah Bolu; Ibrahim Gundogmus; Ozcan Uzun

doi:10.5455/PBS.20220902114034

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Original Research

PBS. 2023; 13(3): 117-124

doi: 10.5455/PBS.20220902114034

The Effects of Treatment Regimens in Accordance with International Guidelines Among Turkish Patients with Schizophrenia: A Single-Center Naturalistic Observation Study

Serdar Atik, Abdullah Bolu, Ibrahim Gundogmus, Ozcan Uzun.

Abstract
Objective: The aim of this study was to learn the current and former treatment regimens of
patients with schizophrenia, and to examine the suitability of treatment period to international
treatment guidelines.
Methods: This naturalistic and retrospective study included 315 cases who applied to the
psychiatry clinic and met the diagnosis criteria for schizophrenia according to the DSM-5.
The severity of disease was evaluated with the Positive and Negative Syndrome
Scale(PANSS) and the Clinical Global Impressions Scale(CGI). The current and former
treatment approaches were examined according to the recommendations of international
treatment guidelines(NICE, APA, TMAP).
Results: Considering the current treatments of the patients, the rate of antipsychotic
monotherapy was 69.5%, the usage rate of long-acting antipsychotic was 41.9% and the rate
of clozapine treatment was 11.4%. Of the patients with sufficient information about their
history of treatment, 70.62% were found to have treatment approaches compatible with
international treatment guidelines. It was found that CGI, PANSS negative and PANSS total
scores of those with a treatment regime compatible with the treatment algorithm were
significantly lower.
Conclusion: It is necessary to have sufficient information about the medical history of
patients to plan a rational, safe and effective treatment compatible with the treatment
guidelines. Regular patient follow-up in a certain center significantly contributes to learning
the necessary patient data. It was found in the evaluations that treatment approaches
compatible with the guidelines have a positive effect on the severity of disease.

Key words: Antipsychotics, guidelines, psychosis, schizophrenia, treatment

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Pubmed Style

Atik S, Bolu A, Gundogmus I, Uzun O. The Effects of Treatment Regimens in Accordance with International Guidelines Among Turkish Patients with Schizophrenia: A Single-Center Naturalistic Observation Study. PBS. 2023; 13(3): 117-124.

doi:10.5455/PBS.20220902114034

Web Style

Atik S, Bolu A, Gundogmus I, Uzun O. The Effects of Treatment Regimens in Accordance with International Guidelines Among Turkish Patients with Schizophrenia: A Single-Center Naturalistic Observation Study. https://www.pbsciences.org/?mno=111014 [Access: June 27, 2026].

doi:10.5455/PBS.20220902114034

AMA (American Medical Association) Style

Atik S, Bolu A, Gundogmus I, Uzun O. The Effects of Treatment Regimens in Accordance with International Guidelines Among Turkish Patients with Schizophrenia: A Single-Center Naturalistic Observation Study. PBS. 2023; 13(3): 117-124.

doi:10.5455/PBS.20220902114034

Vancouver/ICMJE Style

doi:10.5455/PBS.20220902114034

Harvard Style

Atik, S., Bolu, . A., Gundogmus, . I. & Uzun, . O. (2023) The Effects of Treatment Regimens in Accordance with International Guidelines Among Turkish Patients with Schizophrenia: A Single-Center Naturalistic Observation Study. PBS, 13 (3), 117-124.

doi:10.5455/PBS.20220902114034

Turabian Style

Atik, Serdar, Abdullah Bolu, Ibrahim Gundogmus, and Ozcan Uzun. 2023. The Effects of Treatment Regimens in Accordance with International Guidelines Among Turkish Patients with Schizophrenia: A Single-Center Naturalistic Observation Study. Psychiatry and Behavioral Sciences, 13 (3), 117-124.

doi:10.5455/PBS.20220902114034

Chicago Style

Atik, Serdar, Abdullah Bolu, Ibrahim Gundogmus, and Ozcan Uzun. "The Effects of Treatment Regimens in Accordance with International Guidelines Among Turkish Patients with Schizophrenia: A Single-Center Naturalistic Observation Study." Psychiatry and Behavioral Sciences 13 (2023), 117-124.

doi:10.5455/PBS.20220902114034

MLA (The Modern Language Association) Style

doi:10.5455/PBS.20220902114034

APA (American Psychological Association) Style

doi:10.5455/PBS.20220902114034

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